Pädiatrische Onkologie
2009
Eyrich M, Wiegering V, Lim A, Schrauder A, Winkler B, Schlegel PG (2009): Immune function in children under chemotherapy for standard risk acute lymphoblastic leukemia - a prospective study of 20 paediatric patients.
Br J Haematol, 147(3):360-370.
Schlegel PG, Wölfl M, Schick J, Winkler B, Eyrich M (2009): Transient loss of consciousness in pediatric recipients of dimethylsulfoxide (DMSO)-cryopreserved peripheral blood stem cells independent of morphine co-medication.
The Haematology Journal, 94(10):1473-1475, 2099.
Straathof KC, Rao K, Eyrich M, Hale G, Bird P, Berrie E, Brown L, Schlegel PG, Goulden N, Gaspar HB, Gennery AR, Landais P, Davies EG, Brenner MK, Veys P, and Amrolia P (2009): Haematopoietic stem cell transplantation with antibody-based minimal intensity conditioning: a phase 1/2 study.
Lancet, 374(9693):912-920.
Herrera L, Bostrom B. Gore L, Sandler E, Lew G, Schlegel PG, Aquino V, Ghetie V, Vitetta ES, Schindler J (2009). A phase 1 study of combotox in pedaitric patients with refractory B-lineage acute lymphoblastic leukemia.
J Pediatr Hematol Oncol, 31(12):936-941.
Wiegering V, Eyrich M, Wunder C, Günther H, Schlegel PG, Winkler B. (2009): Age related changes in intracellular cytokine expression in healthy children.
Eur Cytokine Netw, 20(2)75-80.
Van Dorp S, Pietersna F, Wölfl M, Verdonck LF, Petersen EJ, Lokhorst HM, Martens E, Theobald M, vam Baarle D, Meijer E, Kuball J (2009). Rituximab treatment before reduced-intensity conditioning transplantation associates with a decreased incidence of extensive chronic GVHD.
Biol Blood Marrow Transplant 15(6):671-768, 2009.
von Hoff K, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C, Benesch M, Warmuth-Metz M, Soerensen N, Zwiener I, Goette H, Schlegel PG, Pietsch T, Kortmann RD, Kuehl J, Rutkowski S (2009): Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT91.
Eur J Cancer 45:1209-1217
Von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S (2009). Large cell/anaplastic medulloblastoma: Outcome according to myc status, histopathological, and clinical risk factors.
Pediatr Blood Cancer, in press.
Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JEA, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortman RD, Pietsch T, Kuehl J (2009): Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy.
Neuro Oncology, 11(2):201-210
Benesch M, Siegler N, Hoff K, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C (2009). Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study.
Anticancer Drugs 20(9).794-799.
Schneider D, Monoranu CM, Huang B, Rutkowski S, Gerber NU, Krauss J, Puppe B, Roggendorf W (2009). Pediatric supratentorial ependymoma show more frequent deletions on chromosome 9 than infratentorial ependymomas: a microsatellite analysis.
Cancer Genet Cytogenet 191(2):90-96.
Häcker S, Dittrich A, Mohr A, Schweitzer T, Rutkowski S, Krauss J, Debatin M, Fulda S (2009). Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Oncogene 28:3097-3110.
Pfister S, Remke M, Brenner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A (2009): Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.
J Clin Oncol 27(10):1627-1636
Schneider D, Momoranu CM, Huang B, Rutkowski S, Gerber NU, Krauss J, Puppe B, Roggendorf W (2009): Pediatric supratentorial ependymomas show more frequent deletions on chromosome 9 than infratentorial ependymomas: a microsatellite analysis.
Cancer Genet Cytogenet 191(2):90-96
Menaa F, Houben R, Eyrich M, Broecker EB, Becker JC, Wischhusen J (2009): Stem cells, melanoma and cancer stem cells : the good, the bad and the evil?
G Ital Dermatol Venereol 144(3):287-296
Wachter-Giner T, Bieber I, Warmuth-Metz, Bröcker EB, Hamm (2009): Multiple pilomatricomas and gliomatosis cerebri – a new association?
Pediatr Dermatol 26(1):75-78
Van Dorp S, Pietersma F, Wölfl M, Verdonck LF, Petersen EJ, Lokhorst HM, Martens E, Theobald M, van Baarle D, Meijer E, Kuball J (2009): Rituximab treatment before reduced-intensity conditioning transplantation associates with a decreased incidence of extensive chronic GVHD.
Biol Blood Marrow Transplant (6):671-678
Kuball J, Hauptrock B, Malina V, Antunes E, Voss RH, Wölfl M, Strong R, Theobald M, Greenberg PD (2009): Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain.
J Exp Med 206(2):463-475
2008
De Vleeschouwer S, Fieuws S, Rutkowski S, Van Calenbergh F, van Loon J, Goffin J, Sciot R, Wilms G, Demaerel P, Warmuth-Metz M, Soerensen N, Wolff J, Wagner S, Kaempgen E, Van Gool S (2008): Clinical experience of postoperative adjuvant dendritic cell-based immunotherapy in a large group of patients with relapsed glioblastoma multiforme.
Clin Cancer Res 14:3098-104
Lang P, Müller I, Greil J, Bader P, Schumm M, Pfeiffer M, Hölle W, Klingebiel T, Heinzelmann F, Belka C, Schlegel PG, Kremens B, Wössmann W and Handgretinger R (2008): Retransplantation with stem cell from mismatched related donors after graft rejection in pediatric patients.
Blood Cells Mol Dis 40:33-9
Schilbach K, Frommer K, Meier, S, Handgretinger R, Eyrich M (2008): Immune response of human propagated gammadelta-T-cells to neuroblastoma recommend the Vdelta1+ subset for gammadelta-T-cell-based immunotherapy.
J Immunother 31:896-905
Wölfl M, Kuball J, Eyrich M, Schlegel PG, Greenberg PD (2008): Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities.
Cytometry A 73:1043-9
Wölfl M, Rutebemberwa A, Mosbruger T, Mao Q, Li H, Netski D, Ray SC, Pardoll D, Sidney J, Sette A, Allen T, Kuntzen T, Kavanagh DG, Kuball J, Greenberg PD, Cox AL (2008): Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.
J Immunol 181: 6435-46
Simon A, Ammann RA, Bode U, Fleischhack G, Wenchel HM, Schwammborn D, Gravou C, Schlegel PG, Rutkowski S, Dannenberg C, Koerholz D, Laws HJ, Kramer MH (2008): Healthcare-associated infections in pediatric cancer patients: Results of a prospective surveillance study from University Hospitals in Germany and Switzerland.
BMC Infectious Diseases 8:70
Beer M, Stenzel M, Girschick H, Schlegel PG and Darge K (2008): Whole-body imaging in children with supsected osteonecrosis after intensive chemotherapy: Preliminary results.
Fortschr Röntgenstr 180:238-45
Riethmueller J, Vonthein R, Borth-Bruhns T, Grassme H, Eyrich M, Schilbach K, Stern M, Gulbins E. (2008): DNA quantification and fragmentation in sputum after inhalation of recombinant human deoxyribonuclease.
Cell Physiol Biochem 22:347-52
Rutkowski S, Fleischhack G (2008): Medulloblastome, primitiv neuroektodermale Tumoren und Ependymome.
Monatsschr Kinderheilkd 156:1165-72
Rutkowski S, Fleischhack G, Gnekow A, Kramm C, Müller H, Calaminus G, Wrede B, Frühwald M, Krauss J, Faldum A, Kortmann RD, Pietsch T, Warmuth M (2008): Hirntumoren bei Kindern und Jugendlichen: Leitsymptome und diagnostische Standards.
Monatsschr Kinderheilkd 156:1187-93
von Hoff K, Kieffer V, Habrand JL, Kalifa C, Dellatolas G, Gill J (2008): Impairment of intellectual functions after surgery and posterior fossa irradiation in children with edendymoma is related to age and neurologic complications.
BMC Cancer 8 (15)
Hasselblatt M, Jozwiak J, Mayer K, Monoranu CM, Schweitzer T, Gerber NU, Krauss J, Schropp C, Bleier S, Kotulska K, Rutkowski S, Pietsch T, Sorensen N, Roggendorf W, Paulus W (2008): Hypothalamic papillary tumor in a patient with tuberous sclerosis.
Am J Surg Pathol 32:1578-80
Huang J, Grotzer M, Watanabe T, Hewer E, Pietsch T, Rutkowski S, Ohgaki H (2008): Mutations in the Nijmegen breakage syndrome gene (NBS1) in medulloblastomas.
Clin Cancer Res 14:4053-8
Monoranu CM, Huang B, Lukashova-v. Zangen I, Rutkowski S, Vince GH, Gerber NU, Puppe B and Roggendorf W (2008): Correlation between chromosome 6q25.3 deletion status and survival in pediatric intracranial ependymomas.
Cancer Gen Cytogenetics 182:18-26
Reinhard H, Reinert J, Beier R, Furtwängler R, Alkasser M, Rutkowski S, Frühwald M, Koscielniak E, Leuschner I, Kaatsch P, Graf N. Rhabdoid tumors in children (2008): Prognostic factors in 70 patients diagnosed in Germany.
Oncol Rep 19:819-23
Warmuth-Metz M, Bison B, Dannemann-Stern E, Kortmann R, Rutkowski S, Pietsch T (2008): CT and MR imaging in atypical teratoid/rhabdoid tumors of the central nervous system.
Neuroradiology 50:447-52
Wolff JEA, Kramm C, Kortmann RD, Pietsch T, Rutkowski S, Jorch N, Gnekow A, Hernaiz Driever P (2008): Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma.
2007
Eyrich M, Winkler B and Schlegel PG (2007): Stem cell transplantation in Fanconi anemia - recent advances with alternative donors.
In: Schindler D, Hoehn H (eds): Fanconi Anemia. A Paradigmatic Disease for the Understanding of Cancer and Aging.
Monogr Hum Genet 15:173–182
Schilbach K, Schick J, Wehrmann M, Wollny G, Simon P, Schlegel P G, Eyrich M (2007): PD-1–PD-L1 pathway is involved in suppressing alloreactivity of heart infiltrating T cells during murine GvHD across minor histocompatibility antigen barriers.
Transplantation 84:214-222
Rutkowski S, von Bueren A, von Hoff K, Hartmann W, Shalaby T, Deinlein F, Warmuth-Metz M, Soerensen N, Emser A, Bode U, Mittler U, Urban C, Benesch M, Kortmann RD, Schlegel PG, Kuehl J, Pietsch T, Grotzer M (2007): Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT’91.
Clin Cancer Res 13 (9):2651-2657.
Rutkowski S. (2007): How can we optimize the timely referral of children with suspected CNS malignancies?
Lancet Oncol 8 (8):664.
Hinkes BG, von Hoff K, Deinlein F, Warmuth-Metz M, Soerensen N, Timmermann B, Mittler U, Urban C, Bode U, Pietsch T, Schlegel PG, Kortmann RD, Kuehl J, and Rutkowski S (2007): Childhood pineoblastoma: Experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91.
J Neurooncol, 81(2): 217-223
Grotzer MA, von Hoff K, von Bueren AO, Shalaby T, Hartmann W, Warmuth-Metz M, Emser A, Kortmann RD, Kuehl J, Pietsch T, Rutkowski S. (2007): Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT’91 - Implications for investigating childhood medulloblastoma.
Klin Paediatr 219:312-7.
Lukashova V, Zangen I, Kneitz S, Monoranu CM, Rutkowski S, Hinkes B, Vince GH, Huang B, Roggendorf W (2007): Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival.
Acta Neuropathol 113(3) 325-337
Pfister S, Remke M, Toedt G, Werft W, Benner A, Mendrzyk F, Wittmann A, Devens F, von Hoff K, Rutkowski S, Kulozik A, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A (2007): Supratentorial Primitive Neuroectodermal Tumors of the Central Nervous System (stPNETs) Frequently Harbor Deletions of the CDKN2A Locus and Other Genomic Aberrations Distinct from Medulloblastomas.
Genes Chromosomes Cancer 46:839-851.
Wölfl M, Kuball J, Ho WY, Nguyen H, Manley TJ, Bleakley M, Greenberg PG (2007): Activation-induced expression of CD137 permits detection, isolation and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of knowledge of epitope specificities.
Blood 110(1):201-210
Kuball J, Dossett ML, Wölfl M, Ho WY, Voss RH, Fowler C, Greenberg PG (2007): Facilitating matched pairing and expression of TCR chains introduced into human T cells.
Blood 109(6):2331-2338
2006
Abele-Horn M, Vogel U, Klare I, Konstabel C, Trabold R, Kurihara R, Witte W, Kreth W, Schlegel PG and Claus H (2006): Molecular epidemiology of hospital-acquired vamcomycin-resistant enterococci. J Clin Microbiol 44:4009-4013
Kramm CM, Wagner S, van Gool S, Schmid H, Strater R, Gnekow A, Rutkowski S, Wolff JE (2006): Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies. Anticancer Res 26:3773-3779
Rutkowski S (2006): Current treatment approaches to early childhood medulloblastoma Expert Rev Neurother 6:1211-1221
Wagner S, Benesch M, Berthold F, Gnekow AK, Rutkowski S, Strater R, Warmuth-Metz M, Kortmann RD, Pietsch T and Wolff JE (2006): Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas.
Br J Cancer 23:991-997, 2006
Wagner S, Warmuth-Metz M, Emser A, Gnekow AK, Strater R, Rutkowski S, Jorch N, Schmid HJ, Berthold F, Graf N, Kortmann RD, Pietsch T, Sorensen N, Peters O and Wolff JE (2006) : Treatment options in childhood pontine gliomas.
J Neurooncol 79:281-287
Timmermann B, Kortmann RD, Kuhl J, Rutkowski S, Meisner C, Pietsch T, Deinlein F, Urban C, Warmuth-Metz M, Bamberg M (2006): Role of radiotherapy in supratentorial primitive neuroectodermal tumor in young children: results of the German HIT-SKK87 and HIT-SKK92 trials.
J Clin Oncol 24:1554-1560
Ho WY, Nguyen HN, Wölfl M, Kuball J, Greenberg PD (2006): In vitro methods for generating CD8+ T-cell clones for immunotherapy from the naive repertoire.
J Immunol Methods 310(1-2):40-52
2005
Eyrich M, Burger G, Marquardt K, Budach W, Schilbach K, Niethammer D, Schlegel PG (2005): Sequential expression of adhesion and costimulatory molecules in GvHD target organs after murine bone marrow transplantation across minor histo-compatibility antigen barriers.
Biology of Blood and Marrow Transplant 11:371-382
Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brügger D, Schilbach K, Winkler B, Bader P, Lang P, Niethammer D, Schlegel PG (2005): Onset of thymic recovery and plateau of thymic function are differentially regulated after stem cell transplantation in children.
Biology of Blood and Marrow Transplant 11:194-205
Kerst G, Kreyenberg H, Roth C, Well C, Dietz K, Coustan-Smith E, Campana D, Koscielniak E, Niemayer C, Schlegel PG, Müller I, Niethammer D, Bader P (2005): Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR.
Br J Haematol 128:774-782
Feuchtinger T, Richard C, Pfeiffer M, Neuhauser F, Lucke J, Handgretinger R, Greil J, Bader P, Klingebiel T, Schlegel PG, Jahn G, Niethammer D and Lang P (2005) : Adenoviral infections after transplantation of positive selected stem cells from haploidentical donors in children.
Klin Pädiatrie 217(6):339-344.
Klingebiel T, Lang P, Schumm M, Köhl U, Bader P, Schwabe D, Schlegel PG, Eyrich M, Greil J, Beck JF, Niethammer D, Handgretinger R (2005): Experiences with haploidentical stem cell transplantation in children with acute lymphoblastic leukemia.
Pathol Biol 53:159-161
Lang P, Schumm M, Greil J, Bader P, Klingebiel T, Muller I, Feuchtinger T, Pfeiffer M, Schlegel PG, Niethammer D, Handgretinger R (2005): A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study.
Klin Pädiatrie 217(6):334-338.
Wölfl M, Jungbluth AA, Garrido F, Cabrera T, Meyen-Southard S, Spitz R, Ernestus K, Berthold (2005): Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma.
Cancer Immunol Immunother 54(4):400-406
Schilbach K, Kerst G, Walter S, Eyrich M, Wernet D, Handgretinger R, Xie W, Rammensee HG, Müller I, Bühring HJ, Niethammer D (2005): Cytotoxic minor histocompatibility antigen HA1-specific CD8+ effector memory T cells: Artificial APCs pave the way for clinical application by potent primary in vitro induction.
Blood 106:144-149
2004
Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff J, Kortmann R, Kuehl J (2005): Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.
N Engl J Med, 352 (10): 978-86
Rutkowski S, De Vleeschouwer S, Kaempgen E, Wolff JEA, Kuehl J, Demaerel P, Warmuth-Metz M, Flamen P, Van Calenbergh F, Plets C, Soerensen N, Opitz A, Van Gool SW (2004): Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma. A feasibility study.
Br J Cancer, 91:1656-62
De Vleeschouwer S, Van Calenbergh F, Demaerel P, Flamen P, Rutkowski S, Kaempgen E, Wolff JEA, Plets C, Sciot R, Van Gool SW (2004): Transient local response and persistent tumor control of recurrent malignant glioma treated with combination therapy including dendritic cell therapy.
J Neurosurg (Pediatrics), 100 (5):492-497
Eyrich M, Leiler C, Croner T, Lang P, Schumm M, Mascher B, Schilbach K, Bader P, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG (2004): Impaired T-cell activation and cytokine productivity after transplantation of positively selected CD34+ allogeneic hematopoietic stem cells.
The Hematology Journal 5:329-340
Schilbach K, Schick J, Fluhr H, Marquordt K, Schütt B, Wehrmann M, Schlegel PG, Niethammer D, Eyrich M (2004): Organ-specific T cell receptor repertoire during graft-versus-host disease after transplantation across minor histocompatibility antigen barriers.
Transplantation, 78:31-40
Lang P, Klingebiel T, Bader P, Greil J, Schumm M, Schlegel PG, Eyrich M, Mueller-Weihrich S, Niethammer D, Handgretinger R (2004): Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases.
Bone Marrow Transplant 33:25-32.
Lang P, Greil J, Bader P, Handgretinger R, Klingebiel T, Schumm M, Schlegel PG, Feuchtinger T, Pfeiffer M, Scheel-Walter H, Fuhrer M, Martin D and Niethammer D. Long-term outcome after hapoidentical stem cell transplantation in children.
Blood Cells Mol Dis. 33(3): 281-287
Kühl J, Rutkowski S, Schlegel PG: Hirntumoren. In: Speer/Gahr (Hrsg) (2004): Pädiatrie, 2. Auflage, Kapitel 28 Hirntumoren (Springer-Verlag, Heidelberg)
Kortmann RD, Timmermann B, Rutkowski S, Bamberg M (2004): Re: B. Beuthien et al. Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. Strahlenther.
Onkol, 180:245 [Comment]
Rutkowski S (2004): HIT 2000. Multizentrische Therapie-Optimierungsstudie zur Behandlung von Kindern und jungen Erwachsenen mit einem intrakranial lokalisierten primitiv neuroektodermalen Tumor (PNET/Medulloblastom) und Ependymom.
Forum Deutsche Krebsgesellschaft, 4:61-63
Rutkowski S (2005): Medulloblastome/PNET. In: Gadner/Gaedicke/Niemeyer/Ritter (Hrsg): Pädiatrische Hämatologie und Onkologie, Kapitel 44.3.1. (Springer-Verlag, Heidelberg)
Rutkowski S, Gnekow A, Wolff J (2004): Multimodale Therapiekonzepte für Kinder und Jugendliche mit Hirntumoren.
Journal Onkologie, 08:25-29
Wolff JEA, Rutkowski S, Kortmann RD (2004): Hirntumoren im Kindesalter. In: Schmoll/Höffken/Possinger (Hrsg): Kompendium Internistische Onkologie,
4. Auflage. Kapitel 153. Hirntumoren im Kindesalter (Springer-Verlag, Heidelberg)
Wölfl M, Schalk S, Hellmich M, Huster KM, Busch DH, Berthold F (2004): Quantitation of MHC tetramer-positive cells from whole blood: evaluation of a single-platform, six-parameter flow cytometric method. Cytometry 57(2):120-130
2003
Burger B, Zimmermann M, Mann G, Kühl J, Loning L, Riehm H, Reiter A, Schrappe M (2003): Diagnostic cerebrospinal fluid examination in children with a lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture.
J Clin Oncol 21: 184-188
Eyrich M, Leiler C, Lang P, Schilbach K, Schumm M, Bader P, Greil J, Klingebiel T, Handgretinger R, Niethammer D, Schlegel PG (2003): A prospective comparison of immune reconstitution in pediatric recipients of positively selected CD34+ peripheral blood stem cells from unrelated donors versus recipients of unmanipulated bone marrow from related donors.
Bone Marrow Transplantation32: 379-390
Kuci S, Wessels JT, Buehring HJ, Schilbach K, Schumm M, Seitz G, Löffler J, Bader P, Schlegel PG, Niethammer D, Handgretinger R (2003): Identification of a novel class of human adherent CD34-stem cells that give rise to SCID-repopulating cells.
Blood 101(3): 869 – 876.
Lang P, Handgretinger R, Niethammer D, Schlegel PG, Schumm M, Greil J, Bader P, Engel C, Scheel-Walter H, Eyrich M, Klingebiel T (2003): Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia.
Blood 101: 1613-1636
Lehrnbecher T, Deinlein F, Marx A, Kühl J (2003): Mediastinal T-cell lymphoma in a boy 7 years after treatment supratentorial primitive neuroectodermal tumor.
J Pediatr Hematol Oncol 25: 657-659
Lehrnbecher T, Trusen A, Deinlein F, Höcht B, Marx A, Kühl J (2003): B-Cell Lymphoproliferative disorder not associated with Epstein-Barr Virus in a child with relapsed acute lymphoblastic leukaemia.
Med Pediatr Oncol 40: 13-17
Ljungman P, Ribaud P, Eyrich M, Matthes-Martin S, Einsele H, Bleakley M, Machaczka M, Bierings M, Bosi A, Gratecos N, Cordonnier C. (2003): Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.
Bone Marrow Transplant. 31:481-486.
Tomaske M, Bosk A, Eyrich M, Bader P, Niethammer D. (2003) Risks of mortality in children admitted to the paediatric intensive care unit after haematopoietic stem cell transplantation.
Br J Haematol. 121:886-891
2002
Eyrich M, Croner T, Leiler C, Lang P, Klingebiel T, Niethammer D, Schlegel PG (2002): Distinct contributions of CD4 and CD8 naive and memory T-cell subsets to overall TCR-repertoire complexity following transplantation of T-cell depleted CD34 selected hematopoietic progenitor cells from unrelated donors.
Blood 100:1915-1918
Huang B, Starostik P, Kühl J, Tonn JC, Roggendorf W (2002): Loss of heterozygosity on chromosome 22 in human ependymomas.
Acta Neuropathol 103: 415-420
Lehrnbecher T, Stanescu A, Kühl J (2002): Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.
Infection 30: 17-21
Müller HL, Marx A, Trusen M, Schneider P, Kühl J (2002): Disseminated malignant ectomesenchymoma (MEM): case report and review of the literature.
Pediatr Hematol Oncol 19: 9-17
Warmuth-Metz M, Kühl J (2002): Neuroradiological differential diagnosis in medulloblastomas and ependymomas: results of the HIT’91-study.
Klin Pädiatr 214: 162-166
Wolff JE, Wagner S, Sindichakis M, Pietsch T, Gnekow A, Kortman RD, Strater R, Kühl J (2002): Simultaneus radiochemotherapy in pediatric patients with I grade glioma: a phase I study.
Anticancer Res. 22: 3569-3572
Wolff JE, Westphal S, Molenkamp G, Gnekow A, Warmuth-Metz M, Rating D, Kühl J (2002): Treatment of paediatric pontine glioma with oral trophosphamide and etoposide.
Br J Cancer 87: 945-949
Wolff JE, Gnekow AK, Kortmann RD, Pietsch T, Urban C, Grad N, Kühl J (2002): Preradiation chemotherapy for pediatric patients with high-grade glioma.
Cancer 94: 264-271
Timmermann B, Kortmann RD, Kühl J, Willich N, Bamberg M (2002): Interdisciplinary therapy of childhood ependymomas.
Strahlenther Onkol. 178: 469-479
Timmermann B, Kortmann RD, Kühl J, Meisner C, Dieckmann K, Pietsch T, Bamberg M (2002): Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91.
J Clin Oncol. 20: 842-849
2001
Eyrich M, Lang P, Lal S, Bader P, Handgretinger R, Klingebiel T, Niethammer D, Schlegel PG (2001): A prospective analysis of the pattern of immune reconstitution in a pediatric cohort following transplantation of positively selected HLA-disparate hematopoietic stem cells from parental donors.
Br J Haematol 114: 422-432
Handgretinger R, Klingebiel T, Lang P, Schumm M, Neu S, Geiselhardt A, Bader P, Schlegel PG, Greil J, Stachel D, Herzog RJ, Niethammer (2001): Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children.
Bone Marrow Transplant 27(8):777-783
Vince GH, Herbold C, Klein R, Kühl J, Pietsch T, Franz S, Roosen K, Tonn JC (2001): Medulloblastoma displays distinct regional matrix metalloprotease expression.
J Neurooncol 53:99-106
Girschick HJ, Klein R, Scheurlen WG, Kühl J (2001): Cytogenetic and histopathologic studies of supratentorial primitive neuroectodermal tumors . a case report.
Pathol Oncol Res 7(1):67-71
Creutzig U, Ritter J, Zimmermann M, Hermann J, Gadner H, Sawatzki DB, Niemeyer CM,Schwabe D, Selle B, Boos J, Kühl J, Feldges A (2001): Idarubicin improves blast cell clearance during induction therapy in children with AML: results of AML-BFM 93.
Leukemia 15(3):348-354
2000
Lal S, Lauer U, Niethammer D, Beck JF, Schlegel PG (2000). Suicide Genes : Past, Present and Future Perspectives.
Immunology Today 421: 48-54.
Schlegel PG, Eyrich M, Bader P, Handgretinger R, Lang P, Niethammer D, and Klingebiel T (2000): OKT-3 based reconditioning regimen for early graft failure in HLA-nonidentical transplants.
Br J Haematol 111: 668-673
Chen Y, Zeng D, Schlegel PG, Fidler J, Chao NJ (2000): PG27, an extract of tripterygium wilfordii hook f., induces antigen specific tolerance in bone marrow transplantation in mice.
Blood 95: 705-710
Bader P, Stoll K, Huber S, Geiselhardt A, Handgretinger R, Niemeyer C, Einsele H, Schlegel PG, Niethammer D, Beck J, Klingebiel T (2000): Characterization of lineage specific chimerism in patients with acute leukemia and MDS after allogeneic SCT before and after relapse.
Br J Haematol 108(4):761-768
Haber HP, Schlegel PG, Dette S, Ruck P, Klingebiel T, Niethammer D (2000): Intestinal graft-versus host disease: findings on sonography.
Am J Roentgenology 174:118-120
Reinhardt D, Behnke-Marcsh J, Weiss E, Christen HJ, Kühl J, Lahomek M, Pekrun A (2000): Rhabdoid tumors of the central nervous system.
Childs Nerv Syst 16(4):228-234
Kortmann RD, Kühl J, Timmermann B, Mittler U, Urban C, Budach V, Richter E, Willich N, Flentje M, Berthold F, Slavic I, Wolff J, Meisner C, Wiestler O, Sörensen N, Warmuth-Metz M, Bamberg M (2000): Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT’91.
Int J Radiat Biol Phys 46(2):269-279.
Seidemann K, Henze G, Beck JD, Sauerbrey A. Kühl J, Mann G, Reiter A (2000): Non-Hodgkin’s lymphoma in pediatric patients with chromosomal breakage syndromes )AT and NBS): experience from the BFM trials.
Ann Oncol 11(Suppl1):141-145
